Prior to first use, seperate the inserts from the covers. Wash the covers & inserts seperately. Wash covers once in hot water. Wash & dry the inserts a minimum of 4 times before use, seperate from any of your other diapers, covers or inserts. Once the Berry Plush diapers & inserts have been prepped, you are free to wash them in with your other diapers, covers, and inserts.